Nos tutelles


Nos fédérations

Nos partenaires


Accueil > Scientific events > Past seminars

Weekly seminar UGSF - Jean-François Collet - June 1st 2018 - CCHB - Amphitheater


"How bacteria protect their cell envelope "

Animated by : Jean-François Collet, Research Director - Institut de Duve - Université Catholique de Louvain

Guest of team "Génétique des enveloppes bactériennes" Jean-Marie Lacroix, de l’UMR 8576 - Université de Lille

Résumé :

Gram-negative bacteria are surrounded by a complex cell envelope, which consists of two concentric membranes separated by the periplasm, a viscous compartment containing a single layer of peptidoglycan (PG). This envelope, a permeability and structural barrier, is essential for cell shape and growth. Proteins important for its integrity are therefore attractive targets for new antibiotics. Over the last 10 years, our laboratory has made important contributions to the unraveling of the pathways involved in the assembly and protection of the envelope. In my talk, I will first describe how the lipoprotein RcsF controls the activation of the Rcs system, a major stress signaling cascade conserved in enterobacteria. I will show that, in contrast to the widely accepted model that lipoproteins face the periplasm, RcsF is continuously exported to the cell surface. I will discuss recent findings on how RcsF can become surface-exposed. I will also highlight the importance of the inter-membrane distance. I will finally address the problem of protein repair in the cell envelope by explaining how we recently identified a novel enzymatic pathway that uses electrons from the respiratory chain to repair oxidatively damaged proteins in the periplasm.

Friday, June 1st 2018 at 11.00 at CCHB - Amphitheater