Integrative modelling of protein complexes with ATTRACT
Dr Sjoerd de Vries
Technische Universitat, Munchen
Computational assembly of protein complexes
Abstract
Protein complexes are essential therapeutic targets in a large variety of biological processes. ATTRACT is a versatile engine for the modelling of protein complexes from semi-rigid components : proteins, domains, peptides, nucleic acids, and other molecules. Key features of ATTRACT are its coarse-grained force field, multiple strategies to incorporate structural flexibility, experimental restraints, and the simultaneous assembly of many components. Moreover, ATTRACT has dedicated protocols for cryo-EM data (ATTRACT-EM), single-stranded RNA, and protein-peptide docking (pepATTRACT). ATTRACT is accessible through a user-friendly web interface :
(http://www.attract.ph.tum.de/services/ATTRACT/attract.html)