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Accueil > Scientific events > Past seminars

Seminar - Dr Tuomo Glumoff - Tuesday June 27th - CCHB Amphitheatre

Structural and functional studies on glycosyltransferase dimers

Tuesday June 27th
CCHB/IRCICA Amphitheatre

by Dr. Tuomo Glumoff,
University Lecturer, Adjunct Professor, and the Dean of Education at the Faculty of Biochemistry and Molecular Medicine of the University of Oulu in Finland.

The visit is made possible by support from the Institut Francais de Finlande, the Embassy of France in Finland, the French Ministry of Education, Higher Education and Research and the Finnish Society of Science and Letters.

Abstract :

Glycosyltransferases (GTases) transfer sugar moieties to/from glycan or polysaccharide molecules. GTases form an important group of enzymes in the Golgi, where synthesis and modification of glycoproteins and glycolipids take place. Golgi GTases are almost invariably type II integral membrane proteins with the C-terminal globular catalytic domain located in the Golgi lumen. GTases are divided into 103 families based on their sequences, and there is an abundance of crystal structures of the catalytic domains. All of these domains possess either of the two characteristic folds, GT-A or GT-B, or present a variation thereof. Since it is known that GTases can function as dimers in vivo, we have analysed the dimerization interface in crystal structures of GTases in the light of available biochemical data. Initially all 898 GTase crystal structures in the Protein Data Bank were considered and a set of 24 enzymes analysed in detail. Results from structure-function studies of GTases will be discussed.