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Home > Scientific events > Past seminars

Seminar of the UGSF - 15th september 2017


"The senescence of cells in aging: role of the endoplasmic reticulum"

By :
Olivier Pluquet of the team "Initiation des Cancers Epithéliaux à l’UMR 8161 (Biology Institute of Lille)"

Invited by the team "O-GlcNacylation, signalisation et cycle cellulaire"

Resume :

The effects of aging on the body are accompanied, in most organs, by an increase in the number of senescent cells that are viable but have lost their ability to divide. The accumulation of senescent cells is directly responsible for the appearance of certain tissue dysfunctions and probably pathologies such as neurodegenerative diseases or cancer. It becomes crucial to understand which molecular actors govern the establishment and maintenance of the senescent phenotype. Our results point to the pathways from the endoplasmic reticulum as essential to this process. The endoplasmic reticulum is an organelle sensitive to changes in the environment of the cells (oxidative stress in particular). In response to these changes, an adaptive mechanism is activated: UPR (for Unfolded Protein Response). This mechanism is controlled by three pathways: PERK, IRE1a, ATF6a, and leads to an overall reduction in protein synthesis and to the activation of chaperones, among others, to restore ER homeostasis and control survival of cells. Although senescence itself is an adaptive response to various stresses (including oxidative stress), altering the functions of ER, the contribution of UPR pathways in the context of senescence and aging remains blurred. The study of ER signaling pathways thus represents a new field of investigation to better understand the mechanisms of cellular aging and can contribute to the identification of components that could represent new exploitable targets for the development of anti- aging.

On the Friday 15th of september 2017 at 11.00 am at the UGSF - Salle André Verbert

This will be followed by a moment of conviviality