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Accueil > Animation scientifique > Séminaires passés

Séminaire hebdomadaire de l’UGSF - 12 mai 2017


" Sex differences in Ketamine’s antidepressant effect "

Conférencier : Professor Mohamed Kabbaj - College of Medicine Florida State University

Invité par l’équipe

" Glycobiologie des Maladies Liées au Stress"

Summary : "Current medications for major depression suffer from numerous limitations and take several weeks to improve mood. However, recent clinical studies have shown that a single low-dose injection of ketamine, an N-methyl d-aspartate receptor (NMDAR) antagonist, has rapid antidepressant effects that are observed within hours and are long lasting, even in patients who do not respond well to various other anti-depressants. In this lecture, I will share some of our preclinical findings regarding sex differences in ketamine antidepressant effects and the role of gonadal hormones in these differences. I will also briefly share some of the recent findings surrounding the safety of ketamine as treatment for depression".

Biographical sketch :

Professor Kabbaj earned his Ph.D. at Bordeaux II University (France) under the supervision of Professor Stefania Maccari, and then completed five years of postdoctoral study at the Mental Health Research Institute at the University of Michigan (Ann Arbor) with Dr. Huda Akil. Then, Dr. Kabbaj joined the department of biomedical sciences at the Florida State University College of Medicine in August 2002 where he went through the academic ranks, and was promoted full professor with tenure at FSU in 2012. Dr. Kabbaj’s research focus on understanding the neurobiology underlying individual differences and sex differences in depression and drug addiction. Another focus of his research is to examine epigenetic mechanisms underlying social behaviors in the monogamous specie prairie voles. Dr. Kabbaj has more than 80 publications, many of which are in excellent journals like Nature Neuroscience, Neuron, Journal of Neuroscience, etc. Dr. Kabbaj has been funded throughout his career by grants from the National Institute of Mental Health and the National Institute of Drug addiction.

Le Vendredi 12 mai 2017 à 11h00 à l’UGSF - Bâtiment C9 - Salle Bernard Fournet