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Accueil > Research > Research teams > O-GlcNAcylation, cell signaling and cell cycle > Publications

O-GlcNAcylation, cell signaling and cell cycle


FARDINI Y., PEREZ-CERVERA Y., CAMOIN L., PAGESY P., LEFEBVRE T, ISSAD T. Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified. Biochem. Biophys. Res. Commun., 2015, pii : S0006-291X(15)00834-7. doi : 10.1016/j.bbrc.2015.04.114.

LEFEBVRE T., ISSAD T. 30 Years Old : O-GlcNAc Reaches the Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation. Front. Endocrinol. (Lausanne). 2015 Feb 9 ;6:17. doi : 10.3389/fendo.2015.00017. eCollection 2015.

ANQUEZ F., SIVERY A., EL YAZIDI - BELKOURA I., ZEMMOURI J., SURET P., RANDOUX S., COURTADE E . Chapter IV : Production of singlet oxygen by direct photo-activation of molecular oxygen. In Singlet Oxygen : Applications in Biosciences and Nanosciences, 2015, in press.

VERCOUTTER-EDOUART A.S., EL YAZIDI-BELKOURA I., GUINEZ C., BALDINI S., LETURCQ M., MORTUAIRE M., MIR A.M., STEENACKERS A., DEHENNAUT V., PIERCE A., LEFEBVRE T. Detection and identification of O-GlcNAcylated proteins by proteomic approaches. Proteomics, 2015, 15 (5-6), 1039-1050.

NAGNAN-LE MEILLOUR P., VERCOUTTER-EDOUART A.S., HILLIOU F., LE DANVIC C., LEVY F. Proteomic Analysis of Pig (Sus scrofa) Olfactory Soluble Proteome Reveals O-Linked-N-Acetylglucosaminylation of Secreted Odorant-Binding Proteins. Front. Endocrinol. (Lausanne), 2014, 5, 202 doi : 10.3389/fendo.2014.00202. eCollection 2014.

HOEDT E., CHAOUI K., HUVENT I., MARILLER C., MONSARRAT B., BURLET-SCHILTZ O., PIERCE A. SILAC-based proteomic profiling of the human MDA-MB-231 metastatic breast cancer cell line in response to the two antitumoral lactoferrin isoforms : the secreted lactoferrin and the intracellular delta-lactoferrin. PLoS One, 2014, 9 (8), e104563.

DEHENNAUT V., LEPRINCE D., LEFEBVRE T. O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins. Front. Endocrinol. (Lausanne). 2014 Sep 26 ;5:155. doi : 10.3389/fendo.2014.00155. eCollection 2014.

HARDIVILLÉ S., ESCOBAR-RAMIREZ A., PINA-CANCECO S., ELASS E., PIERCE A. Delta-lactoferrin induces cell death via the mitochondrial death signaling pathway by upregulating bax expression. Biometals, 2014, 27 (5), 875-889.

OLIVIER-VAN STICHELEN S., DEHENNAUT V., BUZY A., ZACHAYUS J.L., GUINEZ C., MIR A.M., EL YAZIDI-BELKOURA I., COPIN M.C., BOUREME D., LOYAUX D., FERRARA P., LEFEBVRE T. O-GlcNAcylation stabilizes b-catenin through direct competition with phosphorylation at threonine 41. FASEB J., 2014, 28 (8), 3325-3338.

WANG S., SHEN D.L., LAFONT D., VERCOUTTER-EDOUART A.S., MORTUAIRE M., SHI Y., MANITI O., GIRARD-EGROT A., LEFEBVRE T., PINTO M., VOCADLO D., VIDAL S. Design of glycosyltransferase inhibitors targeting human O-GlcNAc Transferase (OGT). Med. Chem. Com., 2014, 5, 1172-1178

BENAMROUZ S., CONSEIL V., CHABÉ M., PRAET M., AUDEBERT C., BLERVAQUE R., GUYOT K., GAZZOLA S., MOURAY A., CHASSAT T., DELAIRE B., GOETINCK N., GANTOIS N., OSMAN M., SLOMIANNY C., DEHENNAUT V., LEFEBVRE T., VISCOGLIOSI E., CUVELIER C., DEI-CAS E., CREUSY C., CERTAD G. Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model. Dis. Model. Mech., 2014, 7 (6), 693-700.

BERRABAH W., AUMERCIER P., GHEERAERT C., DEHONDT H., BOUCHAERT E., ALEXANDRE J., PLOTON M., MAZUY C., CARON S., TAILLEUX A., EECKHOUTE J., LEFEBVRE T., STAELS B., LEFEBVRE P. Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR). Hepatology, 2014, 59 (5), 2022-2033.

DEHENNAUT V., LEFEBVRE T. Proteomics and PUGNAcity will overcome questioning of insulin resistance induction by nonselective inhibition of O-GlcNAcase. Proteomics, 2013, 13 (20), 2944-2946.

FARDINI Y., DEHENNAUT V., LEFEBVRE T., ISSAD T. O-GlcNAcylation : A New Cancer Hallmark ? Front. Endocrinol. (Lausanne), 2013, Aug 12 ;4:99. doi : 10.3389/fendo.2013.00099. eCollection 2013.

CENCI U., CHABI M., DUCATEZ M., TIRTIAUX C., NIRMAL-RAJ J., UTSUMI Y., KOBAYASHI D., SASAKI S., SUZUKI E., NAKAMURA Y., PUTAUX J.L., ROUSSEL X., DURAND-TERRASSON A., BHATTACHARYA D., VERCOUTTER-EDOUART A.S., MAES E., ARIAS M.C., PALCIC M., SIM L., BALL S.G., COLLEONI C. Convergent evolution of polysaccharide debranching defines a common mechanism for starch accumulation in cyanobacteria and plants. Plant Cell. 2013, 25 (10), 3961-3975.

ANQUEZ F., EL YAZIDI BELKOURA I., SURET P., RANDOUX S., COURTADE E. Cell death induced by direct laser activation of singlet oxygen at 1270 nm. Laser Physics, 2013, 23 (2) at

LEFEBVRE T, DROUGAT L, OLIVIER-VAN STICHELEN S, MICHALSKI JC, VERCOUTTER-EDOUART AS. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol. Biol. 2013, 1022, 147-159

PEREZ-CERVERA Y., DEHENNAUT V., AQUINO GIL M., GUEDRI K., SOLÓRZANO MATA C.J., OLIVIER-VAN STICHELEN S., MICHALSKI J.C., FOULQUIER F., LEFEBVRE T. Insulin signaling controls the expression of O-GlcNAc transferase and its interaction with lipid microdomains. FASEB J., 2013, 27 (9), 3478-3486.

CRISTINI-ROBBE O., RAULIN K., DUBART F., UWIMANIMPAYE A., BERNARD R., KINOWSKI C., DAMENE N., EL YAZIDI I., BOED A., TURRELL S. Porous silica supports for micro-Raman spectroscopic studies of individual living cells. J. Mol. Structure, 2013, 3 (2) 232-237.

CRISTINI-ROBBE O., RUYFFELAERE F., DUBART F., UWIMANIMPAYE A., KINOWSKI C., BERNARD R., ROBBE-MASSELOT C., EL YAZIDI I., TURRELL S. Local Drug Delivery Strategy for Cancer Treatment : Use of Biocompatible Sol-Gel-Derived Porous Materials. New Journal of Glass and Ceramics, 2013 3, 74-79

MARILLER C., HARDIVILLÉ S., HOEDT E., HUVENT I., PINA-CANSECO S., PIERCE A. Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor. Biochem. Cell. Biol., 2012, 90(3), 307-319.

OLIVIER-VAN STICHELEN S., DROUGAT L., DEHENNAUT V., EL YAZIDI-BELKOURA I., GUINEZ C., MIR A.M., MICHALSKI J.C., VERCOUTTER-EDOUART A.S., LEFEBVRE T. Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression. Oncogenesis, 2012, 1, e36 ; doi:10.1038/oncsis.2012.36

DROUGAT L., OLIVIER-VAN STICHELEN S., MORTUAIRE M., FOULQUIER F., LACOSTE A.S., MICHALSKI J.C., LEFEBVRE T., VERCOUTTER-EDOUART A.S. Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition. Biochim. Biophys. Acta., 2012, 1820 (12), 1839-1848.

MAIRESSE J., VERCOUTTER-EDOUART A.S., MARROCCO J., ZUENA A.R., GIOVINE A., NICOLETTI F., MICHALSKI J.C., MACCARI S., MORLEY-FLETCHER S. Proteomic characterization in the hippocampus of prenatally stressed rats. J. Proteomics, 2012, 75 (6), 1764-1770

LEFEBVRE T. Neurodegeneration : recall sugars, forget Alzheimer’s. Nat. Chem. Biol., 2012, 8 (4), 325-326.

ANQUEZ F., EL YAZIDI- BELKOURA I., RANDOUX S., SURET P., COURTADE E. Cancerous cell death from sensitizer free photoactivation of singlet oxygen. Photochem. Photobiol., 2012, 88, 167-174.

MEHDY A., MORELLE W., ROSNOBLET C., LEGRAND D., LEFEBVRE T., DUVET S., FOULQUIER F. PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells. J. Biochem., 2012, 151 (4), 439-446.

DERYCKE L., STOVE C., VERCOUTTER-EDOUART A.S., DE WEVER O., DOLLÉ L., COLPAERT N., DEPYPERE H., MICHALSKI J.C., BRACKE M. The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells. Int. J. Dev. Biol. 2011, 55 (7-9), 835-840.

OLIVIER-VAN STICHELEN S., GUINEZ C., MIR A.M., PEREZ-CERVERA Y., LIU C., MICHALSKI J.C., LEFEBVRE T. The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of ß-catenin and cell proliferation. Am. J. Physiol. Endocrinol. Metab., 2012, 302 (4), E417-424.

DE WEVER O., SOBCZAK-THÉPOT J., VERCOUTTER-EDOUART A.S., MICHALSKI J.C., OUELAA-BENSLAMA R., STUPACK D.G., BRACKE M., WANG J.Y., GESPACH C., EMAMI S. Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. Int. J. Oncol., 2011, 39 (2), 393-400.

OLIVIER S., MIR A.M., MICHALSKI J.C., LEFEBVRE T. Signaling and metabolic predispositions linked to the colorectal cancer. Med. Sci. (Paris), 2011, 27 (5), 514-520.

GUINEZ C., FILHOULAUD G., RAYAH-BENHAMED F., MARMIER S., DUBUQUOY C., DENTIN R., MOLDES M., BURNOL A.F., YANG X., LEFEBVRE T., GIRARD J., POSTIC C. O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes, 2011, 60 (5),1399-1413.

GROOTAERT C., VAN DE WIELE T., VAN ROOSBROECK I., POSSE-MIERS S., VERCOUTTER-EDOUART A.S., VERSTRAETE W., BRACKE M., VANHOECKE B. Bacterial modulation of the fasting induced adipose factor (FIAF) in an intestinal cell line model : a potential host-microbe crosstalk related to obesity. Commun. Agric. Appl. Biol. Sci. 2011 ;76(1):101-105.

GROOTAERT C., VAN DE WIELE T., VAN ROOSBROECK I., POSSE-MIERS S., VERCOUTTER-EDOUART A.S., VERSTRAETE W., BRACKE M., VANHOECKE B. Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines. Environ. Microbiol., 2011, 13 (7), 1778-1789.

PEREZ-CERVERA Y., HARICHAUX G., SCHMIDT J., DEBIERRE-GROCKIEGO F., DEHENNAUT V., BIEKER U., MEURICE E., LEFEBVRE T., SCHWARZ R.T. Direct evidence of O-GlcNAcylation in the apicomplexan Toxoplasma gondii : a biochemical and bioinformatic study. Amino Acids, 2011, 40 (3), 847-856.

GUINEZ C., MIR A.M., MARTIN N., LEPRINCE D., MICHALSKI J.C., VERGOTEN G., LEFEBVRE T. Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property. Biochem. Biophys. Res. Commun., 2010, 400 (4), 537-542.

LEFEBVRE T., DEHENNAUT V., GUINEZ C., OLIVIER S., DROUGAT L., MIR A.M., MORTUAIRE M., VERCOUTTER-EDOUART A.S., MICHALSKI J.C. Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer’s disease. Biochim. Biophys. Acta., 2010, 1800 (2), 67-79.

HARDIVILLÉ S., HOEDT E., MARILLER C., BENAÏSSA M., PIERCE A. O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin. J. Biol. Chem., 2010, 285,(25), 19205-19218.

HOEDT E., HARDIVILLÉ S., MARILLER C., ELASS E., PERRAUDIN J.P., PIERCE A. Discrimination and evaluation of lactoferrin and delta-lactoferrin gene expression levels in cancer cells and under inflammatory stimuli using TaqMan real-time PCR. Biometals, 2010, 23 (3), 441-452.