Nos tutelles

CNRS

Nos fédérations

Nos partenaires

Rechercher




Accueil > In the headlines

Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

Cauwel M, Sivignon A, Bridot C, Nongbe MC, Deniaud D, Roubinet B, Landemarre L, Felpin FX, Bouckaert J, Barnich N, Gouin SG

Abstract :
We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.

Link to the article : here