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Accueil > Recherche > Equipes de recherche > Computational Molecular Systems Biology > Projects

Computational Molecular Systems Biology

Biological networks

Biological networks are useful approaches to get a view of a biological systems and molecules in their environment at different scales depending on the type of networks. In our work, we use several network representations which include protein-protein interactions networks (PPIN), regulatory networks (RN) and residue interaction networks (RIN). For PPIN and RN nodes represent individual proteins, with the edges either a physical (PPIN) or regulatory (RN) interaction. For RIN the individual residues of a protein (or protein complex) constitute the nodes, with the edges representing a
physical (Van der Waals or Coulomb) interaction. We have developed a tool called RINspector that performs centrality analyses of RIN coupled with flexibility prediction of the corresponding protein chains (more information here).