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Accueil > Recherche > Equipes de recherche > RMN et interactions moléculaires > Publications

RMN et interactions moléculaires

Publications

Ph.D (last 5 years) :

QI Haoling. Interactions de la phospho-protéine neuronale
Tau avec des protéines partenaires comme cibles thérapeutiques dans la maladie d’Alzheimer. Direction : Dr. Isabelle Landrieu. Université Lille - Sciences et Technologies. 10/2015.

DUJARDIN Marie. Etude des interactions structurales et fonctionnelles entre le domaine 2 de la protéine NS5A du virus de l’hépatite C et la Cyclophiline A humaine. Direction : Dr. Xavier Hanoulle. Université Lille - Sciences et Technologies. 25/09/2015

KAMAH Amina. Identification et caractérisation des modifications post-traductionnelles de la protéines Tau : implication dans le processus d’agrégation. Direction : Dr. Guy Lippens et Caroline Smet-Nocca. Université Lille - Sciences et Technologies. 04/2015

LOPEZ Juan. Etude de l’agrégation des proteins intrinséquement désordonées impliquées dans les maladies d’Alzheimer et de Parkinson. These de Doctorat. Direction : Dr. G. Lippens / Pr. P. Cotelle. Université Lille 1 Sciences et Technologies, 27/01/2015.

BONACHERA Fanny. Les triplets pharmacophoriques flous : développement et applications. These de Doctorat. Direction : Dr. G. Lippens / Dr. D Horvath. Université Lille 1 Sciences et Technologies, 12/12/2011.

DACCACHE Anthony. Etude du mécanisme d’agrégation de la protéine Tau et son inhibition par des composés polyphénoliques. These de Doctorat. Direction : Dr. G. Lippens / Pr. P. Cotelle. Université Lille 1 Sciences et Technologies, 09/12/2011.

AMNIAI Laziza. Conséquences fonctionnelles et pathologiques de la phosphorylation de la protéine neuronale Tau impliquée dans la maladie d’Alzheimer. These de Doctorat. Direction : Dr. G. Lippens. Université Lille 1 Sciences et Technologies, 30/03/2010.

HDR (last 5 years) :

SMET-NOCCA Caroline. Régulation structurale et fonctionnnelle de la protéine neuronale Tau par les modifications post-traductionnelles. Implications physiopathologiques de la phosphorylation, l’acétylation et l’O-b-N-acétylglucosaminylation. HDR (Biologie - Aspects Moléculaires et Cellulaires de la Biologie). Direction : Dr G. Lippens. Université Lille 1 Sciences et Technologies, 01/07/2013.

HANOULLE Xavier. Etude des relations structurales et fonctionnelles entre la Cyclophiline A humaine et les protéines NS5A et NS5B du virus de l’hépatite C. HDR (Biologie - Aspects Moléculaires et Cellulaires de la Biologie). Direction : Dr G. Lippens. Université Lille 1 Sciences et Technologies, 01/10/2012.

Publications (last 5 years) :

2016

Danis C.*, Despres C.*, M. bessa L., Malki I., Merzougui H., Huvent I., Qi H., Lippens G., Cantrelle F-X., Schneider R., Hnaoulle X., Smet-Nocca C. Landrieu I. (2016) Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins, J. Vis. Exp. Dec. 27 (118). doi : 10.3791/55001


Mollica L, Bessa LM, Hanoulle X, Jensen MR, Blackledge M, Schneider R. (2016) Binding Mechanisms of Intrinsically Disordered Proteins : Theory, Simulation, and Experiment, Front Mol Biosci. 3, 52. doi : 10.3389/fmolb.2016.00052 Review

Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. (2016) A β-Turn Motif in the Steroid Hormone Receptor’s Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52, Biochemistry. 55(38), 5366-76. doi : 10.1021/acs.biochem.6b00506

Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. (2016) Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases, Nat Commun. 7, 12673. doi : 10.1038/ncomms12673

Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J. (2016) NMR Meets Tau : Insights into Its Function and Pathology, Biomolecules. 6(2), pii : E28. doi : 10.3390/biom6020028 Review

Lopez J, Schneider R, Cantrelle FX, Huvent I, Lippens G. (2016) Studying Intrinsically Disordered Proteins under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy, Angew Chem Int Ed Engl. 55(26), 7418-22. doi : 10.1002/anie.201601850

Schwagerus S, Reimann O, Despres C, Smet-Nocca C, Hackenberger CP. (2016) Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation, J Pept Sci. 22(5), 327-33. doi : 10.1002/psc.2870

Kamah A, Cantrelle FX, Huvent I, Giustiniani J, Guillemeau K, Byrne C, Jacquot Y, Landrieu I, Baulieu EE, Smet C, Chambraud B, Lippens G. (2016) Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes, J Mol Biol. 428(6), 1080-90. doi : 10.1016/j.jmb.2016.02.015

Peruzzini R, Lens Z, Verger A, Dewitte F, Ferreira E, Baert JL, Villeret V, Landrieu I, Cantrelle FX. (2016) 1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26, Biomol NMR Assign. 10(1), 233-6. doi : 10.1007/s12104-016-9673-z

Qi H, Prabakaran S, Cantrelle FX, Chambraud B, Gunawardena J, Lippens G, Landrieu I. (2016) Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase, J Biol Chem. 291(14), 7742-53. doi : 10.1074/jbc.M115.700914
Ahuja P, Cantrelle FX, Huvent I, Hanoulle X, Lopez J, Smet C, Wieruszeski JM, Landrieu I, Lippens G. (2016) Proline Conformation in a Functional Tau Fragment, J Mol Biol. 428(1), 79-91. doi : 10.1016/j.jmb.2015.11.023

2015

Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C. (2015) Stabilizer-Guided Inhibition of Protein-Protein Interactions, Angew Chem Int Ed Engl. 54(52), 15720-4. doi : 10.1002/anie.201507976

Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. (2015) Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice, Nat Commun. 6, 8250. doi : 10.1038/ncomms9250

Sottejeau Y, Bretteville A, Cantrelle FX, Malmanche N, Demiaute F, Mendes T, Delay C, Alves Dos Alves H, Flaig A, Davies P, Dourlen P, Dermaut B, Laporte J, Amouyel P, Lippens G, Chapuis J, Landrieu I, Lambert JC. (2015) Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain, Acta Neuropathol Commun. 3(1), 58. doi : 10.1186/s40478-015-0237-8

Dujardin M, Madan V, Montserret R, Ahuja P, Huvent I, Launay H, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X. (2015) A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication, J Biol Chem. 290(31), 19104-20. doi : 10.1074/jbc.M115.644419

Landrieu I, Verger A, Baert JL, Rucktooa P, Cantrelle FX, Dewitte F, Ferreira E, Lens Z, Villeret V, Monté D. (2015) Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25, Nucleic Acids Res. 43(14), 7110-21. doi : 10.1093/nar/gkv650

Dubois-Deruy E, Belliard A, Mulder P, Bouvet M, Smet-Nocca C, Janel S, Lafont F, Beseme O, Amouyel P, Richard V, Pinet F. (2015) Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure, Cardiovasc Res. 107(1), 56-65. doi : 10.1093/cvr/cvv136

Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, Choi HS, Jeaon NL, Chang KA, Kim HS, Ottmann C, Suh YH. (2015) Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau, FASEB J. June 23, 2015, . doi : 10.1096/10.1096/fj.14-265009

Giustiniani J, Guillemeau K, Dounane O, Sardin E, Huvent I, Schmitt A, Hamdane M, Buée L, Landrieu I, Lippens G, Baulieu EE, Chambraud B. (2015) The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior, FASEB J. 29(8), 3171-81. doi : 10.1096/fj.14-268243

Gandhi NS, Landrieu I, Byrne C, Kukic P, Amniai L, Cantrelle FX, Wieruszeski JM, Mancera RL, Jacquot Y, Lippens G. (2015) A Phosphorylation-Induced Turn Defines the Alzheimer’s Disease AT8 Antibody Epitope on the Tau Protein, Angew Chem Int Ed Engl. 54(23), 6819-23. doi : 10.1002/anie.201501898

Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S. (2015) Tamoxifen Inhibits CDK5 Kinase Activity by Interacting with p35/p25 and Modulates the Pattern of Tau Phosphorylation, Chem Biol. 22(4), 472-482 doi : 10.1016/j.chembiol.2015.03.009

Qi H, Cantrelle FX, Benhelli-Mokrani H, Smet-Nocca C, Buée L, Lippens G. Bonnefoy E, Gala MC, Landrieu I. (2015) Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation, Biochemistry 54(7), 1525-1533 doi : 10.1021/bi5014613

Reimann O, Smet-Nocca C, Hackenberger CP. (2015) Traceless Purification and Desulfurization of Tau Protein Ligation Products, Angew Chem Int Ed Engl. 54(1), 306-10. doi : 10.1002/anie.201408674

2014

Rosseels J, Van den Brande J, Violet M, Jacobs D, Grognet P, Lopez J, Huvent I, Caldara M, Swinnen E, Papegaey A, Caillierez R, Buée-Scherrer V, Engelborghs S, Lippens G, Colin M, Buée L, Galas MC, Vanmechelen E, Winderickx J. Tau Monoclonal Antibody Generation based on Humanized Yeast Models : Impact on Tau Oligomerization and Diagnostics, J Biol Chem., 2014, 290(7), 4059-74. doi : 10.1074/jbc.M114.627919

LOPEZ J, AHUJA P, LANDRIEU I, CANTRELLE FX, HUVENT I, LIPPENS G. H/D exchange of a 15N labelled Tau fragment as measured by a simple Relax-EXSY experiment, J Magn Reson., 2014, 249C, 32-37. doi : 10.1016/j.jmr.2014.10.008

MCDOWELL GS, HINDLEY CJ, LIPPENS G, LANDRIEU I, PHILPOTT A. Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2, BMC Biochem., 2014, 15(1), 24. doi : 10.1186/s12858-014-0024-3

GIGANT B*, LANDRIEU I*, FAUQUANT C, BARBIER P, HUVENT I, WIERUSZESKI JM, KNOSSOW M, LIPPENS G. Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy, J Am Chem Soc., 2014, 136(36), 12615-23. doi : 10.1021/ja504864m

Freville A, Teiilier G, Vandomme A, Pierrot C, Vicogne J, Cantrelle FX, Martoriati A, Cailliau-Maggio K, Khalife J, Landrieu I. Identification of a Plasmodium falciparum inhibitor-2 motif involved in binding and regulation activity of the protein phosphatase type 1, FEBS J., 2014, 281(19), 4519-34. doi : 10.1111/febs.12960

KAMAH A, HUVENT I, CANTRELLE FX, QI H, LIPPENS G, LANDRIEU I, SMET-NOCCA C. Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal tau protein, Biochemistry., 2014, 53(18), 3020-32. doi : 10.1021/bi500006v

Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, Paquet D, Kamah A, Landrieu I, Lippens G, Baulieu EE, Tawk M. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy, Proc Natl Acad Sci USA., 2014, 111(12), 4584-9. doi : 10.1073/pnas.1402645111

LEGER H, SMET-NOCCA C, ATTMANE-ELAKEB A, MORLEY-FLETCHER S, BENECKE AG, EILEBRECHT S. A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes, Genomics Proteomics Bioinformatics., 2014, 12(1), 8-18. doi : 10.1016/j.gpb.2013.11.001

HUVENT I, KAMAH A, CANTRELLE FX, BAROIS N, SLOMIANNY C, SMET-NOCCA C, LANDRIEU I, LIPPENS G. A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge, Biochem Biophys Res Commun., 2014, 445(2), 299-303. doi : 10.1016/j.bbrc.2014.01.161

2013

BORGHGRAEF P, MENUET C, THEUNIS C, LOUIS JV, DEVIJVER H, MAURIN H, SMET-NOCCA C, LIPPENS G, HILAIRE G, GIJSEN H, MOECHARS D, VAN LEUVEN F. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice, PLoS One., 2013, 8(12), e84442. doi : 10.1371/journal.pone.0084442

LAUNAY H., PARENT B., PAGE A., HANOULLE X., LIPPENS G. Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement, Angew Chem Int Ed Engl., 2013, 52(48), 12587-91. 10.1002/anie.201306253

LOPEZ J., AHUJA P., GERARD M., WIERUSZESKI JM., LIPPENS G. A new strategy for sequential assignment of intrinsically unstructured proteins based on (15)N single istotope labelling, J Magn Reson., 2013, 236, 1-6. doi : 10.1016/j.jmr.2013.07.007

SMET-NOCCA C., LAUNAY H., WIERUSZESKI JM., LIPPENS G., LANDRIEU I. Unraveling a phosphorylation event in a folded protein by NMR spectroscopy : phosphorylation of the Pin1 WW domain by PKA, J Biomol NMR., 2013, 55(4), 323-37. doi : 10.1007/s10858-013-9716-z

DELAUNE, A., CABIN-FLAMAN, A., LEGENT, G., GIBOUIN, D., SMET-NOCCA, C., LEFEBVRE, F., BENECKE, A., VASSE, M., RIPOLL, C. 50nm-Scale Localization of Single Unmodified, Isotopically Enriched, Proteins in Cells, Plos One., 2013, 8(2), e56559. doi : 10.1371/journal.pone.0056559

ANDO, K., DOURLEN, P., SAMBO, AV., BRETTEVILLE, A., BELARBI, K., VINGTDEUX, V., EDDARKAOUI, S., DROBECQ, H., GHESTEM, A., BEGARD, S., DEMEY-THOMAS, E., MENLYK, P., SMET-NOCCA, C., LIPPENS, G., MAURAGE, CA., CAILLET-BOUDIN, ML., VERDIER, Y., VINH, J., LANDRIEU, I., GALAS, MC., BLUM, D., HAMDANE, M., SERGENT, N., BUEE, L. Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker, Neurobiol Aging., 2013, 34(3), 757-69. doi : 0.1016/j.neurobiolaging.2012.08.004

2012

ROSNOBLET C., FRITZINGER B., LEGRAND, D., LAUNAY, H. WIERUSZESKI, JM., LIPPENS G., HANOULLE X. Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A, J Biol Chem., 2012, 287(53), 44249-60. doi : 10.1074/jbc.M112.392209

LIPPENS, G., LANDRIEU, I., AMNIAI, L., QI, H., LEROY, A., SMET-NOCCA, C. The phosphorylation code of the neuronal protein Tau, FEBS J., 2012, 279-S1, 51-51. doi :
LIPPENS, G., AMNIAI, L., WIERUSZESKI, J. M., SILLEN, A., LEROY, A., LANDRIEU, I. Towards understanding the phosphorylation code of tau, BIOCHEMICAL SOC T., 2012, 40, 698-703. doi : 10.1042/BST20120050

THEILLET, FX., SMET-NOCCA, C., LIOKATIS, S., THONGWICHIAN, R., KOSTEN, J., YOON, MK., KRIWACKI, RW., LANDRIEU, I., LIPPENS, G., SELENKO, O. Cell signaling, post-translational protein modifications and NMR spectroscopy, J Biomol NMR., 2012, 54(3), 217-36. doi : 10.1007/s10858-012-9674-x

PRABAKARAN, S., LIPPENS, G., STEEN, H., GUNAWARDENA, J. Post-translational modification : nature’s escape from genetic imprisonment and the basis for dynamic information encoding, Wiley Interdiscip Rev Syst Biol Med., 2012, 4(6), 565-83. doi : 10.1002/wsbm.1185

FREVILLE, A., LANDRIEU, I., GARCIA-GIMENO, M. A., VICOGNE, J., MONTBARBON, M., BERTIN, B., VERGER, A., KALAMOU, H., SANZ, P., WERKMEISTER, E., PIERROT, C., AND KHALIFE, J. Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival, J Biol Chem., 2012, 287, 1306-1321. doi : 10.1074/jbc.M111.276865

LEBRUN, P., RAZE, D., FRITZINGER, B., WIERUSZESKI, J. M., BIET, F., DOSE, A., CARPENTIER, M., SCHWARZER, D., ALLAIN, F., LIPPENS, G., AND LOCHT, C. Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis, PLoS One., 2012, 7, e32421. doi : 10.1371/journal.pone.0032421

CARETTE, X., BLONDIAUX, N., WILLERY, E., HOOS, S., LECAT-GUILLET, N., LENS, Z., WOHLKONIG, A., WINTJENS, R., SOROR, S. H., FRENOIS, F., DIRIE, B., VILLERET, V., ENGLAND, P., LIPPENS, G., DEPREZ, B., LOCHT, C., WILLAND, N., AND BAULARD, A. R. Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands, Nucleic Acids Res., 2012, 40, 3018-3030. doi : 10.1093/nar/gkr1113

2011

AMNIAI, L., LIPPENS, G., AND LANDRIEU, I. Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach, Biochem Biophys Res Commun., 2011, 412, 743-746. doi : 10.1016/j.bbrc.2011.08.046

LANDRIEU, I., HANOULLE, X., FRITZINGER, B., HORVATH, D., WIERUSZESKI, J. M., AND LIPPENS, G. Ranking high affinity ligands of low solubility by NMR spectroscopy, ACS Med Chem Letters., 2011, 2, 485-487. doi : 10.1021/ml200039u

BOURRY, D., SINNAEVE, D., GHEYSEN, K., FRITZINGER, B., VANDENBORRE, G., VAN DAMME, E. J., WIERUSZESKI, J. M., LIPPENS, G., AMPE, C., AND MARTINS, J. C. Intermolecular interaction studies using small volumes, Magn Reson Chem 49, 9-15. doi : 10.1002/mrc.2699

DACCACHE, A., LION, C., SIBILLE, N., GERARD, M., SLOMIANNY, C., LIPPENS, G., AND COTELLE, P. Oleuropein and derivatives from olives as Tau aggregation inhibitors, Neurochem Int., 2011, 58, 700-707. doi : 10.1016/j.neuint.2011.02.010

DELATTRE, A. S., SAINT, N., CLANTIN, B., WILLERY, E., LIPPENS, G., LOCHT, C., VILLERET, V., AND JACOB-DUBUISSON, F. Substrate recognition by the POTRA domains of TpsB transporter FhaC, Mol Microbiol., 2011, 81, 99-112. doi : 10.1111/j.1365-2958.2011.07680.x

FAUQUANT, C., REDEKER, V., LANDRIEU, I., WIERUSZESKI, J. M., VERDEGEM, D., LAPREVOTE, O., LIPPENS, G., GIGANT, B., AND KNOSSOW, M. Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly, J Biol Chem., 2011, 286, 33358-33368. doi : 10.1074/jbc.M111.223545

LAMEIRAS, P., BOUDESOCQUE, L., MOULOUNGUI, Z., RENAULT, J. H., WIERUSZESKI, J. M., LIPPENS, G., AND NUZILLARD, J. M. Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR, J Magn Reson., 2011, 212, 161-168. doi : 10.1016/j.jmr.2011.06.021

LANDRIEU, I., SMET-NOCCA, C., AMNIAI, L., LOUIS, J. V., WIERUSZESKI, J. M., GORIS, J., JANSSENS, V., AND LIPPENS, G. Molecular implication of PP2A and Pin1 in the Alzheimer’s disease specific hyperphosphorylation of Tau, PLoS One., 2011, 6, e21521. doi : 10.1371/journal.pone.0021521

LOUIS, J. V., MARTENS, E., BORGHGRAEF, P., LAMBRECHT, C., SENTS, W., LONGIN, S., ZWAENEPOEL, K., PIJNENBORG, R., LANDRIEU, I., LIPPENS, G., LEDERMANN, B., GOTZ, J., VAN LEUVEN, F., GORIS, J., AND JANSSENS, V. Mice lacking phosphatase PP2A subunit PR61/B’delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta, Proc Natl Acad Sci U S A., 2011, 108, 6957-6962. doi : 10.1073/pnas.1018777108

PLAINCHONT, B., MARTINEZ, A., TISSE, S., BOUILLON, J. P., PILARD, F., WIERUSZESKI, J. M., LIPPENS, G., JEANNERAT, D., AND NUZILLARD, J. M. New and old NMR experiments for the resonance assignment of complex oligosaccharides—application to a cyclodextrin derivative, Magn Reson Chem., 2011, 49, 781-787. doi : 10.1002/mrc.2828

PRABAKARAN, S., EVERLEY, R. A., LANDRIEU, I., WIERUSZESKI, J. M., LIPPENS, G., STEEN, H., AND GUNAWARDENA, J. Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions, Mol Syst Biol., 2011, 7, 482. doi : 10.1038/msb.2011

SAMI, F., SMET-NOCCA, C., KHAN, M., LANDRIEU, I., LIPPENS, G., AND BRAUTIGAN, D. L. Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2, Biochemistry., 2011, 50, 6567-6578. doi : 10.1021/bi200553e

SIBILLE, N., HUVENT, I., FAUQUANT, C., VERDEGEM, D., AMNIAI, L., LEROY, A., WIERUSZESKI, J. M., LIPPENS, G., AND LANDRIEU, I. Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein, Proteins., 2011. doi : 10.1002/prot.23210

SMET-NOCCA, C., BRONCEL, M., WIERUSZESKI, J. M., TOKARSKI, C., HANOULLE, X., LEROY, A., LANDRIEU, I., ROLANDO, C., LIPPENS, G., AND HACKENBERGER, C. P. Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation, Mol Biosyst., 2011, 7, 1420-1429. doi : 10.1039/c0mb00337a

VERDEGEM, D., BADILLO, A., WIERUSZESKI, J. M., LANDRIEU, I., LEROY, A., BARTENSCHLAGER, R., PENIN, F., LIPPENS, G., AND HANOULLE, X. Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A, J Biol Chem., 2011, 286, 20441-20454. doi : 10.1074/jbc.M110.182436

2010

BOURRY, D., SINNAEVE, D., GHEYSEN, K., FRITZINGER, B., VANDENBORRE, G., VAN DAMME, E. J., WIERUSZESKI, J. M., LIPPENS, G., AMPE, C., AND MARTINS, J. C. Intermolecular interaction studies using small volumes, Magn Reson Chem., 2010, doi : 10.1002/mrc.2699

COELMONT, L., HANOULLE, X., CHATTERJI, U., BERGER, C., SNOECK, J., BOBARDT, M., LIM, P., VLIEGEN, I., PAESHUYSE, J., VUAGNIAUX, G., VANDAMME, A. M., BARTENSCHLAGER, R., GALLAY, P., LIPPENS, G., AND NEYTS, J. DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A, PLoS One, 2010, 5, e13687. doi : 10.1371/journal.pone.0013687

DEVRED, F., BARBIER, P., LAFITTE, D., LANDRIEU, I., LIPPENS, G., AND PEYROT, V. Microtubule and MAPs : thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR, Methods Cell Biol, 2010, 95, 449-480. doi : 10.1016/S0091-679X(10)95023-1

HANOULLE, X., BADILLO, A., VERDEGEM, D., PENIN, F., AND LIPPENS, G. The domain 2 of the HCV NS5A protein is intrinsically unstructured, Protein Pept Lett, 2010, 17, 1012-1018. doi : 10.2174/092986610791498920

LANDRIEU, I., HANOULLE, X., BONACHERA, F., HAMEL, A., SIBILLE, N., YIN, Y., WIERUSZESKI, J. M., HORVATH, D., WEI, Q., VUAGNIAUX, G., AND LIPPENS, G. Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025, Biochemistry, 2010, 49, 4679-4686. doi : 10.1021/bi1003266

LANDRIEU, I., LEROY, A., SMET-NOCCA, C., HUVENT, I., AMNIAI, L., HAMDANE, M., SIBILLE, N., BUEE, L., WIERUSZESKI, J. M., AND LIPPENS, G. NMR spectroscopy of the neuronal tau protein : normal function and implication in Alzheimer’s disease, Biochem Soc Trans., 2010, 38, 1006-1011. doi : 10.1042/BST0381006

LEROY, A., LANDRIEU, I., HUVENT, I., LEGRAND, D., CODEVILLE, B., WIERUSZESKI, J. M., AND LIPPENS, G. Spectroscopic studies of GSK3beta phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E, J Biol Chem., 2010, 285, 33435-33444. doi : 10.1074/jbc.M110.149419

PLAINCHONT, B., MARTINEZ, A., TISSE, S., BOUILLON, J. P., WIERUSZESKI, J. M., LIPPENS, G., JEANNERAT, D., AND NUZILLARD, J. M. An alternative scheme for the multiplexed acquisition of 1D and 2D NMR spectra, J Magn Reson., 2010, 206, 68-73. doi : 10.1016/j.jmr.2010.06.005