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Accueil > Recherche > Equipes de recherche > Biologie structurale et intégrative > Publications

Biologie structurale et intégrative



Dupré E, Herrou J, Lensink MF, Wintjens R, Vagin A, Lebedev A, Crosson S, Villeret V, Locht C, Antoine R, Jacob-Dubuisson F. Virulence Regulation with Venus Flytrap Domains : Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS. PLoS Pathog., 2015, 11 (3) : e1004700

Roblin P, Dewitte F, Villeret V, Biondi EG, Bompard C. A Salmonella type three secretion effector/chaperone complex adopts a hexameric ring-like structure. J Bacteriol., 2015, 197 (4), 688-98

Kumari S, Saradhi M, Rana M, Chatterjee S, Aumercier M, Mukhopadhyay G, Tyagi RK. Pregnane and Xenobiotic Receptor gene expression in liver cells is modulated by Ets-1 in synchrony with transcription factors Pax5, LEF-1 and c-Jun. Exp Cell Res., 2015, 330 (2), 398-411


Gabel F, Lensink MF, Clantin B, Jacob-Dubuisson F, Villeret V, Ebel C. Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling. Biophys J., 2014 107 (1), 185-96

Villemagne B, Flipo M, Blondiaux N, Crauste C, Malaquin S, Leroux F, Piveteau C, Villeret V, Brodin P, Villoutreix BO, Sperandio O, Soror SH, Wohlkönig A, Wintjens R, Deprez B, Baulard AR, Willand N. Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches. J Med Chem., 2014, 57 (11), 4876-88 28

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Truant S, Pruvot FR, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G. Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res., 2014, 20 (4), 837-46


Roblin P, Lebrun P, Rucktooa P, Dewitte F, Lens Z, Receveur-Brechot V, Raussens V, Villeret V, Bompard C. The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners. Biochim Biophys Acta., 2013, 1834 (12) : 2564-72

Legrand AJ, Choul-Li S, Spriet C, Idziorek T, Vicogne D, Drobecq H, Dantzer F, Villeret V, Aumercier M. The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage. PLoS One, 2013, 8 (2) : e55883

Verger A, Baert JL, Verreman K, Dewitte F, Ferreira E, Lens Z, de Launoit Y, Villeret V, Monté D. The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members. Nucleic Acids Res., 2013, 41 (9), 4847-59

Baelen S, Dewitte F, Clantin B, Villeret V. Structure of the secretion domain of HxuA from Haemophilus influenzae. Acta Crystallogr Sect F Struct Biol Cryst Commun., 2013, 69 (Pt 12), 1322-7

Pini F, Frage B, Ferri L, De Nisco NJ, Mohapatra SS, Taddei L, Fioravanti A, Dewitte F, Galardini M, Brilli M, Villeret V, Bazzicalupo M, Mengoni A, Walker GC, Becker A, Biondi EG. The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti. Mol Microbiol., 2013, 90 (1), 54-71

Jacob-Dubuisson F, Guérin J, Baelen S, Clantin B. Two-partner secretion : as simple as it sounds ? Res Microbiol., 2013, 164 (6), 583-95

Fioravanti A, Fumeaux C, Mohapatra SS, Bompard C, Brilli M, Frandi A, Castric V, Villeret V, Viollier PH, Biondi EG. DNA binding of the cell cycle transcriptional regulator GcrA depends on N6-adenosine methylation in Caulobacter crescentus and other Alphaproteobacteria. PLoS Genet., 2013, 9 (5) : e1003541


Fioravanti A, Clantin B, Dewitte F, Lens Z, Verger A, Biondi EG, Villeret V. Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012, 68 (Pt 9), 1025-9

Flipo M, Willand N, Lecat-Guillet N, Hounsou C, Desroses M, Leroux F, Lens Z, Villeret V, Wohlkönig A, Wintjens R, Christophe T, Kyoung Jeon H, Locht C, Brodin P, Baulard AR, Déprez B. Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. J Med Chem., 2012, 55 (14), 6391-402

Carette X, Blondiaux N, Willery E, Hoos S, Lecat-Guillet N, Lens Z, Wohlkönig A, Wintjens R, Soror SH, Frénois F, Dirié B, Villeret V, England P, Lippens G, Deprez B, Locht C, Willand N, Baulard AR. Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands. Nucleic Acids Res., 2012, 40 (7):3018-30

Flipo M, Desroses M, Lecat-Guillet N, Villemagne B, Blondiaux N, Leroux F, Piveteau C, Mathys V, Flament MP, Siepmann J, Villeret V, Wohlkönig A, Wintjens R, Soror SH, Christophe T, Jeon HK, Locht C, Brodin P, Déprez B, Baulard AR, Willand N. Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. J Med Chem., 2012, 55 (1), 68-83

Fréville A, Landrieu I, García-Gimeno MA, Vicogne J, Montbarbon M, Bertin B, Verger A, Kalamou H, Sanz P, Werkmeister E, Pierrot C, Khalife J. Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival. J Biol Chem., 2012, 287 (2), 306-21


Lens Z, Dewitte F, Van Lint C, de Launoit Y, Villeret V, Verger A. Purification of SUMO-1 modified IκBα and complex formation with NF-κB. Protein Expr Purif., 2011, 80 (2), 211-6

Delattre AS, Saint N, Clantin B, Willery E, Lippens G, Locht C, Villeret V, Jacob-Dubuisson F. Substrate recognition by the POTRA domains of TpsB transporter FhaC. Mol Microbiol., 2011, 81 (1), 99-112

Flipo M, Desroses M, Lecat-Guillet N, Dirié B, Carette X, Leroux F, Piveteau C, Demirkaya F, Lens Z, Rucktooa P, Villeret V, Christophe T, Jeon HK, Locht C, Brodin P, Déprez B, Baulard AR, Willand N. Ethionamide boosters : synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. J Med Chem., 2011, 54 (8), 2994-3010

Bontems F, Verger A, Dewitte F, Lens Z, Baert JL, Ferreira E, de Launoit Y, Sizun C, Guittet E, Villeret V, Monté D. NMR structure of the human Mediator MED25 ACID domain. J Struct Biol., 2011, 174 (1), 245-51

Verreman K, Baert JL, Verger A, Drobecq H, Ferreira E, de Launoit Y, Monte D. The coactivator activator CoAA regulates PEA3 group member transcriptional activity. Biochem J., 2011, 439 (3), 469-77

Séron K, Couturier C, Belouzard S, Bacart J, Monté D, Corset L, Bocquet O, Dam J, Vauthier V, Lecœur C, Bailleul B, Hoflack B, Froguel P, Jockers R, Rouillé Y. Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem., 2011, 286 (20), 17968-81

MERLIN, STECHLY, DE BEAUE, MONTE, LETEURTRE, VAN SEUNINGEN, HUET & PIGNY. Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells. Oncogene, 2011, 30 (22) 2514-2525