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Accueil > Research > Research teams > Glycobiology of stress-related disorders > Publications

Glycobiology of stress-related disorders




Rincel M, Lépinay A, Gabory A, Théodorou V, Koehl M, Daugé V, Maccari S, Darnaudéry M. Early life stressful experiences and neuropsychiatric vulnerability : evidences from human and animal models. Med Sci (Paris). 2016 Jan ;32(1):93-9.

Maccari S, Polese D, Reynaert ML, Amici T, Morley-Fletcher S, Fagioli F. Early-life experiences and the development of adult diseases with a focus on mental illness : The Human Birth Theory. Neuroscience. 2016 May 26.

Gatta E, Lefebvre T, Gaetani S, Dos Santos M, Marrocco J, Mir AM, Cassano T,Maccari S, Nicoletti F, Mairesse J. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer’s disease. Pharmacol Res. 2016 Mar ;105:186-97.


Mairesse J, Gatta E, Reynaert ML, Marrocco J, Morley-Fletcher S, Soichot M,Deruyter L, Camp GV, Bouwalerh H, Fagioli F, Pittaluga A, Allorge D, Nicoletti F,Maccari S. Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats.Psychoneuroendocrinology. 2015 Dec ;62:36-46.

Reynaert ML, Marrocco J, Mairesse J, Lionetto L, Simmaco M, Deruyter L,Allorge D, Moles A, Pittaluga A, Maccari S, Morley-Fletcher S, Van Camp G,Nicoletti F. Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner. Addict Biol. 2015 May 26.

Reynaert ML, Marrocco J, Gatta E, Mairesse J, Van Camp G, Fagioli F, Maccari S, Nicoletti F, Morley-Fletcher S. A self-medication hypothesis for increased vulnerability to drug abuse in prenatally restraint stressed rats. Adv Neurobiol. 2015 ;10:101-20.

Mairesse J, Van Camp G, Gatta E, Marrocco J, Reynaert ML, Consolazione M,Morley-Fletcher S, Nicoletti F, Maccari S. Sleep in prenatally restraint stressed rats, a model of mixed anxiety- depressive disorder. Adv Neurobiol. 2015 ;10:27-44.


Maccari S, Krugers HJ, Morley-Fletcher S, Szyf M, Brunton PJ. The consequences of early-life adversity : neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol. 2014 Oct ;26(10):707-23.

Marrocco J, Reynaert ML, Gatta E, Gabriel C, Mocaër E, Di Prisco S, Merega E, Pittaluga A, Nicoletti F, Maccari S, Morley-Fletcher S, Mairesse J. The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders. J Neurosci. 2014 Feb 5 ;34(6):2015-24.


Marrocco J, Mairesse J, Bucci D, Lionetto L, Battaglia G, Consolazione M, Ravasi L, Simmaco M, Morley-Fletcher S, Maccari S, Nicoletti F. Early life stress causes refractoriness to haloperidol-induced catalepsy. Mol Pharmacol. 2013 Aug ;84(2):244-51.

Mairesse J, Silletti V, Laloux C, Zuena AR, Giovine A, Consolazione M, van Camp G, Malagodi M, Gaetani S, Cianci S, Catalani A, Mennuni G, Mazzetta A, van Reeth O, Gabriel C, Mocaër E, Nicoletti F, Morley-Fletcher S, Maccari S. Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. Int J Neuropsychopharmacol. 2013 Mar ;16(2):323-38.


Marrocco J, Mairesse J, Ngomba RT, Silletti V, Van Camp G, Bouwalerh H, Summa M, Pittaluga A, Nicoletti F, Maccari S, Morley-Fletcher S. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. J Neurosci. 2012 Nov 28 ;32(48):17143-54.

Laloux C, Mairesse J, Van Camp G, Giovine A, Branchi I, Bouret S, Morley-Fletcher S, Bergonzelli G, Malagodi M, Gradini R, Nicoletti F, Darnaudéry M, Maccari S. Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress. Psychoneuroendocrinology. 2012 Oct ;37(10):1646-58.

Mairesse J, Vercoutter-Edouart AS, Marrocco J, Zuena AR, Giovine A, Nicoletti F, Michalski JC, Maccari S, Morley-Fletcher S. Proteomic characterization in the hippocampus of prenatally stressed rats. J Proteomics. 2012 Mar 16 ;75(6):1764-70.

Matrisciano F, Tueting P, Maccari S, Nicoletti F, Guidotti A. Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology. 2012 Mar ;37(4):929-38.


Maccari S, Nicoletti F. Agomelatine : protecting the CNS from the effects of stress. CNS Neurosci Ther. 2011 Oct ;17(5):269-70.

Morley-Fletcher S, Mairesse J, Soumier A, Banasr M, Fagioli F, Gabriel C, Mocaer E, Daszuta A, McEwen B, Nicoletti F, Maccari S. Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats. Psychopharmacology (Berl). 2011 Oct ;217(3):301-13.

Van Waes V, Darnaudéry M, Marrocco J, Gruber SH, Talavera E, Mairesse J, Van Camp G, Casolla B, Nicoletti F, Mathé AA, Maccari S, Morley-Fletcher S. Impact of early life stress on alcohol consumption and on the short- and long-term responses to alcohol in adolescent female rats. Behav Brain Res. 2011 Aug
1 ;221(1):43-9.

Van Waes V, Enache M, Berton O, Vinner E, Lhermitte M, Maccari S, Darnaudéry M. Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats. Psychopharmacology (Berl). 2011 Mar ;214(1):197-208.

Thèses soutenues, Label européen

MARROCCO Jordan. NOVEL INSIGHTS IN THE GLUTAMATERGIC HYPOTHESIS OF DEPRESSION : A NEUROCHEMICAL AND PHARMACOLOGICAL STUDY IN THE RAT MODEL OF PRENATAL RESTRAINT STRESS. Thèse de Doctorat. Direction : Pr. S. Maccari et Dr. Sara Morley-Fletcher. Université Lille 1 Sciences et Technologies, soutenue le 15/12/2012.

REYNAERT Marie-Line. SEX AND ADDICTION : SELF-MEDICATION HYPOTHESIS IN THE RESPONSE TO REWARD IN THE PRENATAL RESTRAINT STRESS MODEL IN RAT. Thèse de Doctorat. Direction : Dr. Sara Morley-Fletcher et Pr. S. Maccari. Université Lille 1 Sciences et Technologies, soutenue le 20/05/2014.