Nos tutelles


Nos fédérations

Nos partenaires


Accueil > Recherche > Equipes de recherche > Régulation de la glycosylation terminale > Publications

Régulation de la glycosylation terminale




WAVELET-VERMUSE C, GROUX-DEGROOTE S, VICOGNE D, COGEZ V, VENTURI G, TRINCHERA M, BRYSBAERT G, KRZEWINSKI-RECCHI MA, BACHIR EH, SCHULZ C, VINCENT A, VAN SEUNINGEN I, HARDUIN-LEPERS A. Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene : B4GALNT2 is transcriptionally regulated by ETS1. Biochim Biophys Acta Gene Regul Mech. 2021 Sep 6:194747.
doi : 10.1016/j.bbagrm.2021.194747

GROUX-DEGROOTE S, VICOGNE D, COGEZ V, SCHULZ C, HARDUIN-LEPERS A. B4GALNT2 controls Sda and SLex antigens biosynthesis in healthy and cancer human colon. Chembiochem. 2021 Aug 16.
doi : 10.1002/cbic.202100363

CAVDARLI S, SCHRÖTER L, ALBERS M, BAUMANN AM, VICOGNE D, LE DOUSSAL JM, MÜHLENHOFF M, DELANNOY P. Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells. Cells. 2021 Jun 11 ;10(6):1468.
doi : 10.3390/cells10061468

GROUX-DEGROOTE S, DELANNOY P Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy. Int J Mol Sci. 2021 Jun 7 ;22(11):6145.
doi : 10.3390/ijms22116145

GROUX-DEGROOTE S, FOULQUIER F, CAVDARLI S, DELANNOY P. Reticular and Golgi glycosylation : Advances and associated diseases. Med Sci (Paris). 2021 Jun-Jul ;37(6-7):609-617.
doi : 10.1051/medsci/2021082
Review in French

BORDRON A, MOREL M, BAGACEAN C, DUEYMES M, POCHARD P, HARDUIN-LEPERS A, JAMIN C, PERS JO. Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases. Int J Mol Sci. 2021 Mar 26 ;22(7):3402.
doi : 10.3390/ijms22073402


VENUTO MT, MARTORELL-RIBERA J, BOCHERT R, HARDUIN-LEPERS A, REBL A, GALUSKA SP. Characterization of the Polysialylation Status in Ovaries of the Salmonid Fish Coregonus maraena and the Percid Fish Sander lucioperca. Cells. 2020 Oct 31 ;9(11):2391.
doi : 10.3390/cells9112391

PETIT D, TEPPA RE, HARDUIN-LEPERS A. A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family. Glycobiology. 2021 Apr 1 ;31(3):243-259.
doi : 10.1093/glycob/cwaa086

HARRUS D, HARDUIN-LEPERS A, GLUMOFF T. Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution.J Struct Biol. 2020 Nov 1 ;212(2):107628.
doi : 10.1016/j.jsb.2020.1076285

DELANNOY C, HUANG C, CODDEVILLE B, CHEN JY, MOUAJJAH D, GROUX-DEGROOTE S, HARDUIN-LEPERS A, KHOO KH, GUERARDEL Y, ELASS-ROCHARD E. Mycobacterium bovis BCG infection alters the macrophage N-glycome. Mol Omics. 2020 Aug 1 ;16(4):345-354.
doi : 10.1039/c9mo00173e

TSUCHIDA A, SENDA M, ITO A, SAITO S, KISO M, ANDO T, HARDUIN-LEPERS A, MATSUDA A, FURUKAWA K, FURUKAWA K. Author Correction : Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. Sci Rep. 2020 Apr 9 ;10(1):6416.
doi : 10.1038/s41598-020-63112-6

GROUX-DEGROOTE S, CAVDARLI S, UCHIMURA K, ALLAIN F, DELANNOY P. Glycosylation changes in inflammatory diseases. Adv Protein Chem Struct Biol. 2020 ;119:111-156.
doi : 10.1016/bs.apcsb.2019.08.008

CAVDARLI S, DELANNOY P, GROUX-DEGROOTE S. O-acetylated Gangliosides as Targets for Cancer Immunotherapy. Cells. 2020 Mar 17 ;9(3):741.
doi : 10.3390/cells9030741

CAVDARLI S., YAMAKAWA N., CLARISSE C., AOKI K., BRYSBAERT G., LE DOUSSAL J.M., DELANNOY P., GUÉRARDEL Y., GROUX-DEGROOTE S. Profiling of O-acetylated Gangliosides Expressed in Neuroectoderm Derived Cells.. Int J Mol Sci. (2020) Int J Mol Sci. 2020 Jan 6 ;21(1). pii : E370.
doi : 10.3390/ijms21010370

GROUX-DEGROOTE S., CAVDARLI S., UCHIMURA K., ALLAIN F., DELANNOY P. Glycosylation changes in inflammatory diseases. Adv Protein Chem Struct Biol. (2020) ;119:111-156.
doi : 10.1016/bs.apcsb.2019.08.008

VENUTO T.M. , DECLOQUEMENT M., MARTORELL RIBERA J., NOEL M., REBL A., COGEZ V., PETIT D., GALUSKA S.P., HARDUIN-LEPERS A. Vertebrate Alpha2,8-Sialyltransferases (ST8Sia) : A Teleost Perspective. Int J Mol Sci. (2020) Jan 14 ;21(2). pii : E513.
doi : 10.3390/ijms21020513


CHANG L.-Y, TEPPA R.E., NOEL M., GILORMINI P.-A., DECLOQUEMENT M., LION C., BIOT C., MIR A.-M., COGEZ V., DELANNOY P., KHOO K.H., PETIT D., GUERARDEL Y., HARDUIN-LEPERS A. Novel zebrafish mono-alpha2,8-sialyltransferase (ST8Sia VIII) : an evolutionary perspective of alpha2,8-sialylation. IJMS (2019) 20, 622. doi:10.3390/ijms20030622.

HASSINEN A., KHODER-AGHA F., KHOSROWABADI E., MENNERICH D., HARRUS D., NOEL M., DIMOVA1 E.Y., GLUMOFF T., HARDUIN-LEPERS A., KIETZMANN T. & KELLOKUMPU S. A Golgi-Associated Redox Switch Regulates Catalytic Activation and Cooperative Functioning of ST6Gal-I with B4GalT-I. Redox Biology (2019) 24:101182. doi : 10.1016/j.redox.2019.101182.

KHODER-AGHA F., HARRUS D., LEPROVOST P., BRYSBAERT G., JUFFER A., LENSINK M., HARDUIN-LEPERS A., GLUMOFF T. & KELLOKUMPU S. Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains. J. Biol. Chem. (2019) 294, 14383-14393. doi:10.1074/jbc.RA119.009539.

CAVDARLI S, DEWALD JH, YAMAKAWA N, GUÉRARDEL Y, TERME M, LE DOUSSAL JM, DELANNOY P, GROUX-DEGROOTE S. Identification of 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2) as main O-acetylated sialic acid species of GD2 in breast cancer cells. Glycoconj J. (2019) 36(1):79-90. doi : 10.1007/s10719-018-09856-w.


YAMAKAWA N., VANBESELAERE J., CHANG L-Y., DUCROCQ L., HARDUIN-LEPERS A., SATO C., KHOO K-H., KITAJIMA K., GUERARDEL Y. Systems glycomics of adult zebrafish identifies organ specific sialylation and glycosylation patterns. Nature communications (2018) November 07, 9, article number 4647. doi:10.1038/s41467-018-06950-3.

NOEL M., GILORMINI P.-A., COGEZ V., LION C., BIOT C., HARDUIN-LEPERS A., GUERARDEL Y. MicroPlate Sialyltransferase Assay (MPSA) : a rapid and sensitive assay based on an unnatural sialic acid donor and bioorthogonal chemistry. Bioconjugate journal (2018) Oct 17 ;29(10):3377-3384. doi : 10.1021/acs.bioconjchem.8b00529.

GROUX-DEGROOTE S., SCHULZ C., COGEZ V., PORTIER L., VICOGNE D., SOLORZANO C., DALL’OLIO F., MORTUAIRE M., GONZALEZ-PESFIL M., HENRY M., FOULQUIER F., HÉLIOT L., HARDUIN-LEPERS A. Extended cytoplasmic tail of the human B4GALNT2 is required for Golgi and vesicles localization. Febs J (2018) 285(18) : 3442-3463. doi : 10.1111/febs.14621.

LEFEBVRE T., DELANNOY P. Disrupting membrane lipids composition promotes tumorigenesis : the other dark side of cholesterol and the potential involvement of gangliosides. Transl. Cancer Res. (2018) 7 (Suppl 5):S587-S590. doi : 10.21037/tcr.2018.04.26

GROUX-DEGROOTE S., RODRÍGUEZ-WALKER M., DEWALD J.H., DANIOTTI J.L., DELANNOY P. Gangliosides in cancer cell signaling. Prog Mol Biol Transl Sci. (2018) 156:197-227. doi : 10.1016/bs.pmbts.2017.10.003

TSUCHIDA A., SENDA M., ITO A., SAITO S., KISO M., ANDO T., HARDUIN-LEPERS A., MATSUDA A., FURUKAWA K., FURUKAWA K. Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. Scientific reports (2018) 8(1):7017. doi : 10.1038/s41598-018-25521-6

DEWALD J.H., CAVDARLI S., STEENACKERS A., DELANNOY C.P., MORTUAIRE M., SPRIET C., NOËL M., GROUX-DEGROOTE S., DELANNOY P. TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines. PLoS One. (2018) 13(4):e0196369. doi : 10.1371/journal.pone.0196369

PETIT D., TEPPA E., CENCI U., BALL S., HARDUIN-LEPERS A. Reconstruction of the sialylation pathway in the ancestor of eukaryotes. Scientific reports (2018) 8(1):2946. doi : 10.1038/s41598-018-20920-1


DI W., FUJITA A., HAMAGUCHI K., DELANNOY P., SATO C., KITAJIMA K. Diverse subcellular localizations of the insect CMP-sialic acid synthetases. Glycobiology (2017) 27(4), 329-341. doi : 10.1093/glycob/cww128

NOEL M., GILORMINI P.-A., COGEZ V., YAMAKAWA N., VICOGNE D., LION C., BIOT C., GUERARDEL Y, HARDUIN-LEPERS A. Probing the CMP-sialic acid donor specificity of two human -D-galactoside sialyltransferases (ST3Gal I and ST6Gal I) selectively acting on O- and N-glycosylproteins. ChemBioChem (2017) 18, 1251-1259. doi : 10.1002/cbic.201700024

DELANNOY C.P., ROMBOUTS Y., GROUX-DEGROOTE S., HOLST S., CODEVILLE B, HARDUIN-LEPERS A., WUHRER M., ELASS-ROCHARD E, GUERARDEL Y. Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages. J Proteome Res. (2017) 16(1):156-169. doi : 10.1021/acs.jproteome.6b00161

GROUX-DEGROOTE S., GUERARDEL Y., DELANNOY P. Gangliosides : Structures, Biosynthesis, Analysis and Roles in Cancer. ChemBioChem. (2017) 18(13), 1146-1154. doi : 10.1002/cbic.201600705

COLOMB F., KRZEWINSKI-RECCHI M.-A., STEENACKERS A., VINCENT A., HARDUIN-LEPERS A., DELANNOY P., GROUX-DEGROOTE S. TNF up-regulates ST3GAL4 and sialyl-LewisX expression in lung epithelial cells through an intronic ATF2 responsive element. Biochem. J. (2017) 474, 65-78. doi : 10.1042/BCJ20160602.


DEWALD J.H., COLOMB F., BOBOWSKI M., GROUX-DEGROOTE S., DELANNOY P. Role of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and Cancer. Cells (2016) 5, 43. doi:10.3390/cells5040043

SZUNERITS S., ZAGORODKO O., COGEZ V., DUMYCH T., CHALOPIN T., ALVAREZ DORTA D., SIVIGNON A., BARNICH N., HARDUIN-LEPERS A., LARROULET I., YANGUAS SERRANO A., SIRIWARDENA A., PESQUERA A., ZURUTUZA A., GOUIN S.G., BOUKHERROUB R., BOUCKAERT J. Differentiation of Crohn’s Disease-Associated Isolates from Other Pathogenic Escherichia coli by Fimbrial Adhesion under Shear Force. Biology (Basel) (2016) Apr 1 ;5(2). pii : E14. doi : 10.3390/biology5020014. https://www-ncbi-nlm-nih-gov.gate1....

DROLEZ A, VANDENHAUTE E, JULIEN S, GOSSELET F, BURCHELL J, CECCHELLI R, DELANNOY P, DEHOUCK MP, MYSIOREK C. Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines. PLoS One. 2016 Mar 9 ;11(3):e0151155. doi : 10.1371/journal.pone.0151155. eCollection 2016. https://www-ncbi-nlm-nih-gov.gate1i...

BAREL M., HARDUIN-LEPERS A., PORTIER L., SLOMIANNY M.-C., CHARBIT A. Host glycosylation pathways and the unfolded protein response contribute to the infection by Francisella. Cell Microbiol. (2016) May 17. doi : 10.1111/cmi.12614 (IF 4.915).

DROLEZ A, VANDENHAUTE E, DELANNOY CP, DEWALD JH, GOSSELET F, CECCHELLI R, JULIEN S, DEHOUCK MP, DELANNOY P, MYSIOREK C. ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier. Int J Mol Sci. 2016 Aug 11 ;17(8). pii : E1309. doi : 10.3390/ijms17081309.

TEPPA E., PETIT D., PLECHAKOVA O., COGEZ V., HARDUIN-LEPERS A. Phylogenetic-derived insights into the evolution of sialylation in Eukaryotes : Comprehensive analysis of Vertebrate β-galactoside α2,3/6-sialyltransferases (ST3Gal and ST6Gal) Int. J. Mol. Sci. (2016) 17, 1286 invited review in special issue “glycan receptor interaction (Ed Cheorl Ho Kim) doi:10.3390/ijms17081286. https://www-ncbi-nlm-nih-gov.gate1....

WOODMAN N, PINDER SE, TAJADURA V, LE BOURHIS X, GILLETT C, DELANNOY P, BURCHELL JM, JULIEN S. Two E-selectin ligands, BST-2 and LGALS3BP, predict metastasis and poor survival of ER-negative breast cancer. Int J Oncol. 2016 Jul ;49(1):265-75. doi : 10.3892/ijo.2016.3521.

DELANNOY C. ; ROMBOUTS Y., GROUX-DEGROOTE S., HOLST S., CODDEVILLE B., HARDUIN-LEPERS A. ; WUHRER M., ELASS-ROCHARD E., GUERARDEL Y. Glycosylation changes triggered by the differentiation of monocytic THP-1 cell line into macrophages J. Prot. Res. (2016) Jun 28.

GILORMINI P.-A., LION C., NOEL M., KRZEWINSKI-RECCHI M.-A., HARDUIN-LEPERS A., GUERARDEL Y, BIOT C. Improved workflow for the efficient preparation of ready to use CMP-activated sialic acid (2016) Glycobiology (IF 3.283). DOI:10.1093/glycob/cww084.

VIDEIRA PA, JULIEN S, LOUREIRO LR, SOUSA DP, CARRASCAL MA, DELANNOY P. Vaccine and antibody therapy against Thomsen–Friedenreich Tumor-Associated Carbohydrate Antigens. In “ Recent Advances in Biotechnology : Recent Progress in Glycotherapy ” Zhou Q. ed., Bentham Science Publishers, Oak Park, IL, USA, 2016, pp. 3-38.


VANDERMEERSCH S., VANBESELAERE J., DELANNOY C.P., DROLEZ A., MYZIOREK C., GUÉRARDEL Y., JULIEN S., DELANNOY P. Accumulation of GD1 ganglioside in MDA-MB-231 breast cancer cells expressing ST6GalNAc V. Molecules (2015) 20, 6913-6924. doi:10.3390/molecules20046913.

GUÉRARDEL Y., GROUX-DEGROOTE S., DELANNOY P. Gangliosphyngolipids : their structure and biological roles. In “Carbohydrate Chemistry : State-of-the-art and challenges for drug development” Cipolla L. ed., Imperial College Press, London, UK (2015) pp. 35-56.

PETIT D., TEPPA R.E., MIR A.-M., VICOGNE D., THISSE C., THISSE B., FILLOUX C. and HARDUIN-LEPERS A. Integrative view of ß–galactoside a2,3-sialyltransferases (ST3Gal) evolutionary relationships and functional divergence in Chordates : Massive st3gal gene loss in Homo sapiens. Mol Biol Evol. 2015, 32(4):906-27. doi : 10.1093/molbev/msu395.

GROUX-DEGROOTE S., GUÉRARDEL Y., JULIEN S., DELANNOY P. Gangliosides in Breast Cancer : New Perspectives. Biochemistry (Mosc). 2015 ; 80(7) : 808-19

MIHALACHE A., DELPLANQUE J.F., RINGOT-DESTREZ B., WAVELET C., GOSSET P., NUNES B., GROUX-DEGROOTE S., LÉONARD R., ROBBE-MASSELOT C. Structural Characterization of Mucin O-Glycosylation May Provide Important Information to Help Prevent Colorectal Tumor Recurrence. Front Oncol. 2015, 5 : 217

GERARDY-SCHAHN R, DELANNOY P, VON ITZSTEIN M. Preface. Top Curr Chem. 2015, 367:v-vii

LOUREIRO L.R., CARRASCAL M.A., BARBAS A., RAMALHO J.S., NOVO C., DELANNOY P., VIDEIRA P.A. Challenges in Antibody Development against Tn and Sialyl-Tn Antigens. Biomolecules. 2015 11 ;5(3) : 1783-809. doi : 10.3390/biom5031783

CIME-CASTILLO J.A., DELANNOY P., MENDOZA-HERNANDEZ G., MONRROY-MARTINEZ V., HARDUIN-LEPERS A., LANZ-MENDOZA H., HERNANDEZ-HERNANDEZ F., ZENTENO-GALINDO E. CABELLO-GUTIERREZ C., RUIZ-ORDAZ B.H. Sialic Acid Expression in the Mosquito Aedes aegypti and its Possible Role in Dengue Virus-Vector Interactions. Biomed Res Int. (2015) 2015 : 504187.


COLOMB F., VIDAL O., BOBOWSKI M., KRZEWINSKI-RECCHI M.-A., HARDUIN-LEPERS A., MENSIER E., JAILLARD S., LAFITTE J.-J., DELANNOY P. and GROUX-DEGROOTE S. TNF induces the expression of ST3Gal IV in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewisx mediated adhesion of Pseudomonas aeruginosa. Biochem. J. 2014, 457(1), 79-87. doi : 10.1042/BJ20130989.

DALL’OLIO F., MALAGOLINI N., CHIRICOLO M., TRINCHERA M. and HARDUIN-LEPERS A. The expanding roles of the Sda/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2. Biochim. Biophys. Acta- General Subjects 2014, 1840(1), 443-453. doi : 10.1016/j.bbagen.2013.09.036.

GROUX-DEGROOTE S, WAVELET C, KRZEWINSKI-RECCHI MA, PORTIER L, MORTUAIRE M, MIHALACHE A, TRINCHERA M, DELANNOY P, MALAGOLINI N, CHIRICOLO M, DALL’OLIO F, HARDUIN-LEPERS A. B4GALNT2 gene expression controls the biosynthesis of Sd(a) and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract. Int J Biochem Cell Biol. 2014, 442-9. doi : 10.1016/j.biocel.2014.06.009.

VAN SLAMBROUCK S, GROUX-DEGROOTE S, KRZEWINSKI-RECCHI MA, CAZET A, DELANNOY P, STEELANT WF. Carbohydrate-to-carbohydrate interactions between a2,3-linked sialic acids on a2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells. Biosci Rep. 2014, 34(5). pii : e00138. doi : 10.1042/BSR20140096.

JULIANT S., HARDUIN-LEPERS A., MONJARET F., CATIEAU B., -VIOLET M.-L., CÉRUTTI P., OZIL A., DUONOR-CÉRUTTI M. Isolation and characterization of the ?1,6-fucosyltransferase gene from the lepidopteran insect cell line Sf9 : insights into fut8 gene evolution in animals. PlosOne 2014, 9, (10) e110422 doi:10.1371/journal.pone.0110422.t001

JULIEN S., DELANNOY P. Sialic Acid and Cancer. In : Taniguchi N., Endo T., Hart G., Seeberger P., Wong C. (Eds.) Glycoscience : Biology and Medicine (2014) SpringerReference ( Springer Japan, pp. 1419-1424.

COLOMB F., ROBBE-MASSELOT C., GROUX-DEGROOTE S., BOUCKAERT J., DELANNOY P., MICHALSKI J.C. Epithelial Mucins and Bacterial Adhesion. Carbohydr. Chem. (2014) 40, 596–623.


HARDUIN-LEPERS A. Vertebrate sialyltransferases. In : Sialobiology : Structure, Biosynthesis and Function. Sialic acid glycoconjugates in health and diseases. Ed. : J. Tiralongo and I Martinez-Duncker, 2013, Chapter 5, pp. 139-187. doi : 10.2174/97816080538651130101

BOBOWSKI M, VINCENT A, STEENACKERS A, COLOMB F, VAN SEUNINGEN I, JULIEN S, DELANNOY P. Estradiol Represses the GD3 Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NF ?B Binding to ST8SIA1 Promoter. PLoS One. 2013, 23 ;8(4):e62559.

HOTTIN A, WRIGHT DW, STEENACKERS A, DELANNOY P, DUBAR F, BIOT C, DAVIES GJ, BEHR JB. a-L-Fucosidase Inhibition by Pyrrolidine-Ferrocene hybrids : Rationalization of Ligand Binding Properties by Structural Studies. Chem. 2013, 19(29), 9526-33. doi : 10.1002/chem.201301001. IF : 5.92

PETIT D., TEPPA R.E., PETIT J.-M., HARDUIN-LEPERS A. A practical approach to reconstruct evolutionary history of animal sialyltransferases and gain insights into the sequence-function relationships of Golgi-glycosyltransferases. Methods in molecular biology, Glycobiology Protocols (2013) 1022, 73-97. doi : 10.1007/978-1-62703-465-4_7.

JULIEN S, BOBOWSKI M, STEENACKERS A, LE BOURHIS X, DELANNOY P. How Do Gangliosides Regulate RTKs Signaling ? Cells. 2013, 2(4):751-67. doi : 10.3390/cells2040751.

MARTINEZ P, VERGOTEN G, COLOMB F, BOBOWSKI M, STEENACKERS A, CARPENTIER M, ALLAIN F, DELANNOY P, JULIEN S. Over-sulfated glycosaminoglycans are alternative selectin ligands : insights into molecular interactions and possible role in breast cancer metastasis. Clin Exp Metastas 2013, 30(7):919-31. doi : 10.1007/s10585-013-9592-7.

JULIANT S., LEVEQUE M., CERUTTI P., OZIL A., CHOBLET S., VIOLET M.-L, SLOMIANNY M.-C., HARDUIN-LEPERS A. and CERUTTI M. Engineering baculovirus genome to produce galactosylated antibodies in lepidopteran cells. Methods in Molecular Biology, Glycobiology Protocols 2013, 988, 59-77. doi : 10.1007/978-1-62703-327-5_5.

BOBOWSKI M., HARDUIN-LEPERS, DELANNOY P. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1). in Handbook of Glycosyltransferases and Related Genes, Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda, Hisashi Narimatsu, Yoshiki Yamaguchi and Takashi Angata, eds. © Sprinter-Verlag Berlin Heidelberg (2013) doi : 10.1007/SpringerReference_332175


HARDUIN-LEPERS A., KRZEWINSKI-RECCHI M.A., COLOMB F., FOULQUIER F., GROUX-DEGROOTE S. and DELANNOY, P. Sialyltransferases function in cancer. Front. Biosci. 2012, 4, 499-515.

GUÉRARDEL Y., CHANG L.-Y., FUJITA A., CODDEVILLE B., MAES E., SATO C., HARDUIN-LEPERS A., KUBOKAWA K. and KITAJIMA K. Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. Glycobiology 2012, 4 (22), 479-491.

VANBESELAERE, J., CHANG L.-Y., HARDUIN-LEPERS A., FABRE E., SLOMMIANNY, C., BIOT C. KHOO K.-H. and GUÉRARDEL Y. Zebrafish liver cells is a coherent model for the study of glycosylation in zebrafish. Journal of proteome research 2012, 11, 2164-2177.

JULIEN S, VIDEIRA PA, DELANNOY P. Sialyl-Tn in cancer , (how) did we miss the target ? Biomolecules 2012, 2, 435-466. doi, 10.3390/biom2040435.

CAZET A, BOBOWSKI M, ROMBOUTS Y, LEFEBVRE J, STEENACKERS A, POPA I, GUÉRARDEL Y, LE BOURHIS X, TULASNE D, DELANNOY P. The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase. Glycobiology. 2012, 22(6), 806-16.

STEENACKERS A, CAZET A, BOBOWSKI M, ROMBOUTS Y, LEFEBVRE J, GUÉRARDEL Y, TULASNE D, LE BOURHIS X, DELANNOY P. Expression of GD3 synthase modifies ganglioside profile and increases migration of MCF-7 breast cancer cells. C. R. Chimie 2012, 15, 3-14.

HOTTIN A, DUBAR F, STEENACKERS A, DELANNOY P, BIOT C, BEHR JB. Iminosugar-ferrocene conjugates as potential anticancer agents. Org Biomol Chem. 2012, 10(29), 5592-7. doi, 10.1039/c2ob25727k.

STEENACKERS A, VANBESELAERE J, CAZET A, BOBOWSKI M, ROMBOUTS Y, COLOMB F, LE BOURHIS X, GUÉRARDEL Y, DELANNOY P. Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase. Molecules. 2012, 17(8), 9559-72.

BOBOWSKI M, CAZET A, STEENACKERS A, DELANNOY P. Role of complex gangliosides in cancer progression. Carbohydr. Chem. 2012, 37, 1-20.

COLOMB F., KRZEWINSKI-RECCHI M.-A., El MACHHOUR F., MENSIER E., JAILLARD S., STEENACKERS A., HARDUIN-LEPERS A., LAFITTE J.-J. DELANNOY P. and GROUX-DEGROOTE S. TNF- ? enhances the expression of sialyl-Lewisx and 6-sulfo-sialyl-Lewisx carbohydrate antigens in human A549 cells and bronchial mucosa through the up-regulation of ST3GAL4 specific transcript. Biochimie 2012, 94, 2045-2053.


AUDRY M., JEANNEAU C., IMBERTY A., HARDUIN-LEPERS A., DELANNOY, P. and BRETON C. Current trends in the structure-activity relationships of the sialyltransferases. Glycobiology 2011, 21 (6), 716-726 . doi, 10.1093/glycob/cwq189.

TEYLAERT B., MEURICE E., BOBOWSKI M., HARDUIN-LEPERS A., GAUCHER C., FONTAYNE A., JORIEUX S. and DELANNOY P. Molecular cloning, characterization, genomic organization and promoter analysis of the alpha1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0 BMC Biotechnology 2011, 11, 1. doi, 10.1186/1472-6750-11-1.

VAN DER POEL S, WOLTHOORN J, VAN DEN HEUVEL D, EGMOND M, GROUX-DEGROOTE S, NEUMANN S, GERRITSEN H, VAN MEER G, SPRONG H. Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity. Traffic. 2011, 12(11), 1634-47.

JULIEN S, IVETIC A, GRIGORIADIS A, QIZE D, BURFORD B, SPROVIERO D, PICCO G, GILLETT C, PAPP SL, SCHAFFER L, TUTT A, TAYLOR-PAPADIMITRIOU J, PINDER SE, BURCHELL JM. Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. Cancer Res. 2011, 71(24), 7683-93.


LEHOUX S, GROUX-DEGROOTE S, CAZET A, DHAENENS CM, MAURAGE CA, CAILLET-BOUDIN ML, DELANNOY P, KRZEWINSKI-RECCHI MA. Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. Glycoconj J. 2010, 27(1), 99-114.

BERNARDIN A, CAZET A, GUYON L, DELANNOY P, VINET F, BONNAFFE D, TEXIER I. Copper-free click chemistry for highly luminescent quantum dot conjugates, application to in vivo metabolic imaging. Bioconjug Chem. 2010, 21(4), 583-8.

CARVALHO A.S., HARDUIN-LEPERS A., MAGALHÃES A., MACHADO E., MENDES N., COSTA L.T., MATTHIESEN R., ALMEIDA R., COSTA J., REIS C.A. Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. Int J Biochem Cell Biol. 2010, 42, 80-89.

HARDUIN-LEPERS A. Comprehensive analysis of sialyltransferases in vertebrate genomes. Glycobiology Insights 2010, 2, 29-61. doi, 10.4137/GBI.S3123.

CAZET A., JULIEN S., BOBOWSKI M., KRZEWINSKI-RECCHI M.-A., HARDUIN-LEPERS A., GROUX-DEGROOTE S., DELANNOY P. Consequences of the expression of sialylated antigens in breast cancer. Carbohydr Res. 2010, 45(10), 1377-1383. ,

CAZET A, JULIEN S, BOBOWSKI M, BURCHELL J, DELANNOY P. Tumour-associated carbohydrate antigens in breast cancer. Breast Cancer Res. 2010, 12(3), 204.

CAZET A, LEFEBVRE J, ADRIAENSSENS E, JULIEN S, BOBOWSKI M, GRIGORIADIS A, TUTT A, TULASNE D, LE BOURHIS X, DELANNOY P. GD3 synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation. Mol Cancer Res. 2010, 8(11), 1526-35.

PETIT D., MIR A.-M., THISSE C., DELANNOY P., ORIOL R., THISSE B. and HARDUIN-LEPERS A. Molecular phylogeny and functional genomics of ß–galactoside a2,6-sialyltransferases to explain ubiquitous expression of st6gal1 in Amniotes. J. Biol. Chem. 2010, 285, 38399-38414. doi, 10.1074/jbc.M110.163931.


DELANNOY P, TEYLAERT B, JORIEUX S, MEURICE E, GAUCHER C, FONTAYNE A, BOBOWSKI M. Utilisation d’un répresseur d’un gène codant une enzyme possédant une activité glycosyltransferase. Brevet n° 10 50857, déposé le 8 février 2010.

Thèses soutenues

AURELIE CAZET : Effet de l’expression de la GD3 synthétase sur la progression et l’agressivité du cancer du sein.
8/12/2010 (UST Lille1)

MARIE BOBOWSKI : Régulation transcriptionnelle et rôle de la GD3 synthétase, enzyme clef de la biosynthèse des gangliosides, dans le cancer du sein.
14/12/2012 (UST Lille1)

FLORENT COLOMB : Régulation de la biosynthèse des épitopes sialyl-Lewisx et 6-sulfo-sialyl-Lewisx par el TNF dans la muqueuse bronchique humaine et influence sur l’adhésion de Pseudomonas aeruginosa.
17/12/2012 (UST Lille1)

AGATA STEENACKERS : Etude du rôle des gangliosides complexes dans la prolifération des cellules de cancer du sein.
28/11/2013 (UST Lille1)

ADRIANA MIHALACHE : Recherche de nouveaux marqueurs diagnostiques et/ou pronostiques pour le cancer du colon.
11/01/2016 (UST Lille1)

Cindy WAVELET : Régulation transcriptionnelle de la B4GALNT2 humaine dans le colon.
16/12/2016 (UST Lille1)

MAXENCE NOEL : Etude des relations structure-fonction des sialyltransférases humaines : développement de nouveaux outils.
07/12/2018 (Université de LILLE, FST)

CAVDARLI Sumeyye : Etude des mécanismes de biosynthèse du GD2 O-acétylée dans le cancer du sein.
23/01/2020 (Université de Lille, FST)

HDR soutenues

MARIE-ANGE KRZEWINSKI-RECCHI : Les sialyltransférases au « sein » des cancers.
19/02/2010 (UST Lille1).

SOPHIE GROUX-DEGROOTE : Anomalies de la glycosylation terminale dans la mucoviscidose et les cancers : régulation des glycosyltransférases.
7/07/2011 (UST Lille1)